SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF BINUCLEAR Fe(III), Co(II), Ni(II), Cu(II) AND Zn(II) COMPLEXES WITH SCHIFF BASE (E)-4-[(HYDROXYL PHENYLIMINO)METHYL]BENZENE-1, 2-DIOL

Schiff base ligand (E)-4-[(hydroxyl phenylimino)methyl]benzene-1, 2-diol (H3L) was prepared from the condensation reaction of Protochatechu aldehyde (3, 4-dihydroxybenzaldhyde) with 2-amino phenol. From the direct reaction of the ligand (H3L) with Co(II), Ni(II) and Cu(II) chlorides and Fe(III) and Zn(II) nitrates in 2M:1L molar ratio, the five new neutral complexes were prepared. The characterization of the newly formed compounds was done by HNMR, UV-Vis and IR spectroscopy and elemental analysis. The in-vitro antibacterial activity and antifungal activity of the metal complexes were studied and compared with that of free ligand. The Cupper complex shows the higher biological activity. INTRODUCTION: Some Schiff bases were tested for fungicidal activity, which is related to their chemical structure , there metal complexes are important in biochemical process. For example, the transamination reactions are catalyzed by metals ions through the formation of intermediate Schiff bases containing vitamin B6 . In the area of bioinorganic chemistry, interest in Schiff base complexes has centered on the role of such complexes in providing synthetic models for the metal containing sites in metallo-proteins and enzymes . Schiff base ligands are potential anticancer drugs 4 and the anticancer activity of this metal complex is enhanced in comparison to the free ligand . 3, 4-dihydroxybenzaldehyde, (Protocatechuaaldehyde, PCA) derivatives were evaluated and showed inhibition for bacteria growth , antioxidants , antitumor , anticorrosion 9 and reagent in simple, rapid and highly sensitive analysis of Cr(VI) and (V) 10 . In the present work, new Schiff base derived from condensation of PCA and 2-amino phenol and its complexes are prepared and investigated using the elemental analysis and UV-Vis, IR, HNMR spectra as well as TGA and the biological activities also are studied.